Select the required mode of notification ( email / sms / web console etc ) and fill in the required fields. Click here to know more about setting up notification profiles generally.
Click on next.
Scroll down to the section that says "When any Virtual Devices has a problem". Click on it and select the situations for which you wish to get alerted.
You can get alerted either for General Alarms ( like VM Power on / off, VM Failover failed, Host disconnect failed etc) or for virtual device related performance issues ( such as threshold violations ) .
Click on Next and continue the steps followed to setup a notification profile ( click here to view the complete list of steps required for setting up notification profile. )